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ACTTION = American Initiative (Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks) – Milestone of 100 publications in April 2019

Aim: To find pain type-specific neurobiological mechanisms

Hernia repair (chronic pain in 10-20%)

Protective influence of COMT & GCH1 on chronic but not acute pain

Total Knee Replacements (20-30% chronic pain)

GCH1 protective on acute but not chronic pain

ORPMI SNPs increased in acute pain

Mastectomy (up to 50% chronic pain)

CACNG2 à post mastectomy pain (lack of genetic data in prospect)

Gender differences in acute pain (Euroanaesthesia 2014)

Male gender – more pain after major surgery

Female gender – more pain after minor surgery


(I cannot guarantee the accuracy of the above content, these notes have been taken at a conference)

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